CLASS TOPICS AND READINGS (Subject to change)

ALL READINGS ARE REQUIRED

January 22:  Description of course and its organization

January 24: History and General Introduction  
                                
Siegel, J. M. (2003). Why we sleep. Scientific American, 289, 92-97.

January 29, 31: History and General Introduction (Amy Jo Marcano-Reik and Andy Gall)

Dement, W. C. (2000). History of sleep physiology and medicine. In M. H. Kryger, T. Roth & W. C. Dement (Eds.), Principles and practice of sleep medicine (pp. 1-14). Philadelphia: W. B. Saunders Company.

Carskadon, M. A., & Dement, W. C. (2000). Normal human sleep:  An overview. In M. H. Kryger, T. Roth & W. C. Dement (Eds.), Principles and practice of sleep medicine (Third ed., pp. 15-25). Philadelphia: W. B. Saunders Company.

Hobson, J. A. (2005). Sleep is of the brain, by the brain and for the brain. Nature, 437, 1254-1256.

February 5, 7: Phenomenology of Sleep

McCarley and Hobson. 1977. The neurobiological origins of psychoanalytic dream theory. The American Journal of Psychiatry, 134: 1211-1221.

Hobson, J. A., & McCarley, R. W. (1977). The brain as a dream state generator: An activation-synthesis hypothesis of the dream process. The American Journal of Psychiatry, 134, 1335-1348.

Aserinsky, E., & Kleitman, N. (1953). Regularly occurring periods of eye motility, and concomitant phenomena, during sleep. Science, 118, 273-274.

February 12, 14: Mechanisms of Sleep

Pace-Schott, E. F., & Hobson, J. A. (2002). The neurobiology of sleep: Genetics, cellular physiology and subcortical networks. Nature Reviews Neuroscience, 3, 591-605.

Siegel, J. M. (2005). REM sleep. In M. H. Kryger, T. Roth & W. C. Dement (Eds.), Principles and practice of sleep medicine. Philadelphia: W. B. Saunders Company.

Massimini, M., Huber, R., Ferrarelli, F., Hill, S., & Tononi, G. (2004). The sleep slow oscillation as a traveling wave. Journal of Neuroscience, 24(31), 6862-6870.

February 19, 21: Development I

Corner MA. Sleep and the beginnings of behavior in the animal kingdom – Studies of ultradian motility cycles in early life. Progress in Neurobiology 8: 279-295, 1977.

Kleitman, N., & Engelmann, T. G. (1953). Sleep characteristics of infants. Journal of Applied Physiology, 6, 269-282.

Roffwarg, H. P., Muzio, J. N., & Dement, W. C. (1966). Ontogenetic development of the human sleep-dream cycle. Science, 152, 604-619.

Rivkees, S. A. (2003). Developing circadian rhythmicity in infants. Pediatrics, 112, 373-381.

February 26, 28: Development II                    

Jouvet-Mounier, Astic et al. 1970. Ontogenesis of the states of sleep in rat, cat, and guinea pig during the first postnatal month. Developmental Psychobiology, 2: 216-239.

Gramsbergen, A., Schwartze, P., & Prechtl, H. F. R. (1970). The postnatal development of behavioral states in the rat. Developmental Psychobiology, 3, 267-280.

Frank, M. G., & Heller, H. C. (2003). The ontogeny of mammalian sleep: A reappraisal of alternative hypotheses. Journal of Sleep Research, 12, 25-34.

Blumberg, M. S., Karlsson, K. Æ., Seelke, A. M. H., & Mohns, E. J. (2005). The ontogeny of mammalian sleep: A response to frank and heller (2003). Journal of Sleep Research, 14, 91-101

March 4, 6: Development III

Karlsson, K. Æ., & Blumberg, M. S. (2005). Active medullary control of atonia in week-old rats. Neuroscience, 130, 275-283.

Karlsson, K. Æ., Gall, A. J., Mohns, E. J., Seelke, A. M. H., & Blumberg, M. S. (2005). The neural substrates of infant sleep in rats. PLoS Biology, 3, 891-901.

Seelke, A. M. H., Karlsson, K. Æ., Gall, A. J., & Blumberg, M. S. (2005). Extraocular muscle activity, rapid eye movements, and the development of active and quiet sleep. European Journal of Neuroscience, 22, 911-920.

Lo, C. C., Chou, T., Penzel, T., Scammell, T. E., Strecker, R. E., Stanley, H. E., & Ivanov, P. C. (2004). Common scale-invariant patterns of sleep-wake transitions across mammalian species. Proceedings of the National Academy of Sciences, 101, 17545-17548.

Blumberg, M. S., Seelke, A. M., Lowen, S. B., & Karlsson, K. A. (2005). Dynamics of sleep-wake cyclicity in developing rats. Proceedings of the National Academy of Sciences, 102, 14860-14864.

March 11, 13: Regulation and Homeostasis

Saper, C. B., Scammell, T. E., & Lu, J. (2005). Hypothalamic regulation of sleep and circadian rhythms. Nature, 437, 1257-1263.

Aston-Jones, G., Chen, S., Zhu, Y., & Oshinsky, M. L. (2001). A neural circuit for circadian regulation of arousal. Nature Neuroscience, 4, 732-738.

Borbely, A. A., & Achermann, P. (2000). Sleep homeostasis and models of sleep regulation. In M. H. Kryger, T. Roth & W. C. Dement (Eds.), Principles and practice of sleep medicine (pp. 377-390). Philadelphia: W. B. Saunders Company.

Mistlberger, R. E., & Rusak, B. (2000). Circadian rhythms in mammals: Formal properties and environmental influences. In M. H. Kryger, T. Roth & W. C. Dement (Eds.), Principles and practice of sleep medicine (pp. 321-333). Philadelphia: W. B. Saunders Company.

March 18, 20:  Spring Break

March 25, 27: Comparative Issues I

Zepelin, H. (2000). Mammalian sleep. In M. H. Kryger, T. Roth & W. C. Dement (Eds.), Principles and practice of sleep medicine (pp. 82-92). Philadelphia: W. B. Saunders Company.

Lyamin, O., Pryaslova, J., Lance, V., & Siegel, J. (2005). Continuous activity in cetaceans after birth. Nature, 435, 1177.

Sekiguchi, Y., Arai, K., & Kohshima, S. (2006). Sleep in continuously active dolphins. Nature, 441, E9-10; discussion E11.

April 1, 3: Comparative Issues II

Hendricks, J. C., Sehgal, A., & Pack, A. (2000). The need for a simple animal model to understand sleep. Progress in Neurobiology, 61, 339-351.

Shaw, P. J., Cirelli, C., Greenspan, R. J., & Tononi, G. (2000). Correlates of sleep and waking in drosophila melanogaster. Science, 287, 1834-1837.

Rattenborg, N. C., Mandt, B. H., Obermeyer, W. H., Winsauer, P. J., Huber, R., Wikelski, M., et al. (2004). Migratory sleeplessness in the white-crowned sparrow (zonotrichia leucophrys gambelii). PLoS Biology, 2, E212.

Raizen, D. M., Zimmerman, J. E., Maycock, M. H., Ta, U. D., You, Y. J., Sundaram, M. V., & Pack, A. I. (2008). Lethargus is a Caenorhabditis elegans sleep-like state. Nature, 451, 569-572.

Yokogawa, T., Marin, W., Faraco, J., Pezeron, G., Appelbaum, L., Zhang, J., Rosa, F., Mourrain, P., & Mignot, E. (2007). Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol, 5, 2379-2397.

April 8, 10: Functions of Sleep I

Rechtschaffen A. The function of sleep: methodological issues. In: Functions of Sleep, edited by Drucket R, Shkurovich M and Sterman MB. New York: Academic Press, 1979, p. 1-17.

Siegel, J. M. (2005). Clues to the functions of mammalian sleep. Nature, 437, 1264-1271.

Rechtschaffen, A., Gilliland, M. A., Bergmann, B. M., & Winter, J. B. (1983). Physiological correlates of prolonged sleep deprivation in rats. Science, 221, 182-184.

April 15, 17: Functions of Sleep II: Sleep and Memory

Stickgold, R. (2005). Sleep-dependent memory consolidation. Nature, 437, 1272-1278.

Vertes, R. P., & Siegel, J. M. (2005). Time for the sleep community to take a critical look at the purported role of sleep in memory processing. Sleep, 28, 1228-1229.

Stickgold and Walker Response

Vertes and Siegel Rebuttal

Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004). Extensive and divergent effects of sleep and wakefulness on brain gene expression. Neuron, 41, 35-43.

April 22, 24: Functions of Sleep III: Sleep and Plasticity

Petersson, P., Waldenström, A., Fåhraeus, C., & Schouenborg, J. (2003). Spontaneous muscle twitches during sleep guide spinal self-organization. Nature, 424, 72-75.

Schouenborg, J. (2004). Learning in sensorimotor circuits. Current Opinion in Neurobiology, 40, 693-697.

Khazipov, R., Sirota, A., Leinekugel, X., Holmes, G. L., Ben-Ari, Y., & Buzsaki, G. (2004). Early motor activity drives spindle-bursts in the developing somatosensory cortex. Nature, 432, 758-761.

Marcano-Reik, A. J., & Blumberg, M. S. Submitted.

April 29, May 1: Sleep Disorders

Siegel, J. M., Moore, R., Thannickal, R., & Nienhuis, R. (2001). A brief history of hypocretin/orexin and narcolepsy. Neuropsychopharmacology, 25, S14-S20.

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B., & Yanagisawa, M. (1999). Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell, 98(4), 437-451.

Blumberg, M. S., Coleman, C., Johnson, E. D., & Shaw, C. S. (2007). Developmental divergence of sleep-wake patterns in orexin knockout and wild-type mice. European Journal of Neuroscience, 25, 512-518.

Mignot, E., Taheri, S., & Nishino, S. (2002). Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nature Neuroscience, 5, 1071-1075.

Mahowald, M. W., & Schenck, C. H. (2005). Insights from studying human sleep disorders. Nature, 437, 1279-1285.

May 6, 8:

TBA

May 12:  Beginning of Examination Week